COL1A2 Polyclonal Antibody

CAT: 0749-ABP51022-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP51022-01Size:30 µL
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Background
COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in COL1A2, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for COL1A2.
Description
Rabbit Anti-COL1A2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
COL1A2; Collagen alpha-2 (I) chain; Alpha-2 type I collagen
Gene ID
1278
Accession Number
P08123
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human COL1A2 at AA range: 440-520
Clonality
Polyclonal
Tag
Collagen alpha-2 (I) chain
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
125kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
COL1A2 Polyclonal Antibody detects endogenous levels of COL1A2 protein.
Observed Molecular Weight
125
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Other Product Names
COL1A2; Collagen alpha-2 (I) chain; Alpha-2 type I collagen
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P08123
Isotype
Rabbit IgG

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