COL11A2 Polyclonal Antibody

• Background:

  COL11A2 encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53) . Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.

• Description:

  Rabbit Anti-COL11A2 Polyclonal Antibody

• Product Name Alternative:

  COL11A2; Collagen alpha-2 (XI) chain

• Gene ID:

  1302

• Accession Number:

  P13942

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from the C-terminal region of human COL11A2 at AA range: 1180-1260

• Clonality:

  Polyclonal

• Tag:

  Collagen alpha-2 (XI) chain

• Applications:

  WB, IHC, IF, ELISA

• Purification Method:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Molecular Weight:

  171kD

• Precautions:

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions:

  Gel pack with blue ice.

• Storage Conditions:

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes:

  COL11A2 Polyclonal Antibody detects endogenous levels of COL11A2 protein.

• Observed Molecular Weight:

  171

• Formulation:

  Liquid solution

• Buffer pH:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes:

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200

• Other Product Names:

  COL11A2; Collagen alpha-2 (XI) chain

• Tested Applications:

  WB, IHC, IF, IP, ELISA

• Host or Source:

  Rabbit

• Accession Number URL:

  http://www.uniprot.org/uniprot/P13942

• CAS Number:

  9007-83-4

• Isotype:

  Rabbit IgG