Claudin-6 Polyclonal Antibody

CAT: 0749-ABP50991-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP50991-01Size:30 µL
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Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN6 encodes a component of tight junction strands, which is a member of the claudin family. Claudin 6 is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
Description
Rabbit Anti-Claudin-6 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CLDN6; Claudin-6; Skullin
Gene ID
9074
Accession Number
P56747
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Claudin-6 at AA range: 50-130
Clonality
Polyclonal
Tag
Claudin-6
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
26kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Claudin-6 Polyclonal Antibody detects endogenous levels of Claudin-6 protein.
Observed Molecular Weight
26
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Other Product Names
CLDN6; Claudin-6; Skullin
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P56747
Isotype
Rabbit IgG

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