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Claudin-11 Polyclonal Antibody

CAT: 0749-ABP55451-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP55451-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CLDN11 encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by CLDN11 is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein claudin 11 is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.
Description
Rabbit Anti-Claudin-11 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein
Gene ID
5010
Accession Number
O75508
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the C-terminal region of human Claudin-11 at AA range: 130-210
Clonality
Polyclonal
Tag
Claudin-11
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
20kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Claudin-11 Polyclonal Antibody detects endogenous levels of Claudin-11 protein.
Observed Molecular Weight
20
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Other Product Names
CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O75508
Isotype
Rabbit IgG

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