Products for Research Use Only

ChemR23 Polyclonal Antibody

CAT: 0749-ABP50970-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP50970-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The C-X3-C chemokine family is characterized by two cysteines separated by three amino acid residues. Fractalkine is a member of this chemokine family that binds CX3CR1, previously named V28, and chemokine b receptor-like 1 (CMKBRL1) with high affinity, to induce either leukocyte adhesion and migration or chemotactic functions. CX3CR1 functions with CD4 as a co-receptor for the HIV-1 virus envelope protein, and patients homozygous for a variant haplotype of CX3CR1 progress to AIDS more rapidly than those with other haplotypes. Chemokine receptor-like 1 (also designated G protein-coupled receptor DEZ or ChemR23) belongs to the G protein-coupled receptor 1 family. It is an integral membrane protein functioning as a receptor, possibly a chem-otactic peptide receptor. It also acts as a coreceptor for various SIV strains and for a primary HIV-1 strain. ChemR23 is highly expressed in developing osseous and cartilaginous tissue, brain, kidney, gastrointestinal tissues and myeloid tissue, as well as in adult parathyroid glands.
Description
Rabbit Anti-ChemR23 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CMKLR1; CHEMR23; DEZ; Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ
Gene ID
1240
Accession Number
Q99788
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human ChemR23 at AA range: 190-270
Clonality
Polyclonal
Tag
Chemokine-like receptor 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
42kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
ChemR23 Polyclonal Antibody detects endogenous levels of ChemR23 protein.
Observed Molecular Weight
42
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:100-300; Not yet tested in other applications.
Other Product Names
CMKLR1; CHEMR23; DEZ; Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q99788
Isotype
Rabbit IgG