Pneumolysin-IN-1

CAT: 0804-HY-163542-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-163542-01Size:5 mg

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Description

Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM) . Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae[1].

CAS Number

330842-49-4

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pneumolysin-in-1.html

Purity

98.08

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC(N(C2=CC(C)=CC(C)=C2)C(/C1=C/C3=CC=C(C4=C(Cl)C=C(Cl)C=C4)O3)=O)=O

Molecular Formula

C23H16Cl2N2O4

Molecular Weight

455.29

References & Citations

[1]Aziz U B A, et al. Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins[J]. Nature Communications, 2024, 15 (1) : 3537.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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