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TIGAR rabbit pAb

CAT: 0855-ES11945-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11945-01Size:50 µL
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Background
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Description
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2, 6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13. 32 region that includes this gene is paralogous to the 11q13. 3 region. [provided by RefSeq, Jul 2008],
UniProt
Q9NQ88
Swiss Prot
Q9NQ88
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
TIGAR
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
29kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
29kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Mitochondrion . Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017) . Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017) . Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (PubMed:25928429) . Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD) /reoxygenation insult in primary neurons (By similarity) . .
Gene ID (Human)
57103

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