Crocin

• Description :

  Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities [1][2].

• Product Name Alternative :

  Crocin I

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Endogenous Metabolite; JAK

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/crocin.html

• Purity :

  99.68

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O[C@@H]([C@H](O)[C@H]1O)[C@H](O[C@H]1OC(/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO)=O)=O)CO[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO

• Molecular Formula :

  C44H64O24

• Molecular Weight :

  976.96

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zaghloul MS, et al. Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis. Life Sci. 2019 Aug 26:116794.|[2]Yang H, et al. Crocin exerts anti-tumor effect in colon cancer cells via repressing the JAK pathway. Eur J Histochem. 2023 Sep 12;67 (3) :3697.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [42553-65-1]