Crocetin

CAT: 0804-HY-N2072-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2072-01Size:5 mg
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Description
Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia[1][2][3][4].
CAS Number
[27876-94-4]
Product Name Alternative
Transcrocetin; trans-Crocetin
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; COX; iGluR; p38 MAPK
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/crocetin.html
Purity
98.07
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(O)/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O)=O
Molecular Formula
C20H24O4
Molecular Weight
328.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Chen B, et al. Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. Biomed Res Int. 2015;2015:829513.|[2]Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. Eur J Pharmacol. 2013 Mar 5;703 (1-3) :1-10.|[3]Choudhary S, et al. Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice. ACS Pharmacol Transl Sci. 2024 Sep 11;7 (10) :3017-3033.|[4]Lautenschläger M, et al. Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22 (1) :36-44.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; NMDA Receptor

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