Crocetin

• Description:

  Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia[1][2][3][4].

• Product Name Alternative:

  Transcrocetin; trans-Crocetin

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; COX; iGluR; p38 MAPK

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/crocetin.html

• Purity:

  98.07

• Solubility:

  DMSO : 20 mg/mL (ultrasonic)

• Smiles:

  O=C(O)/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O)=O

• Molecular Formula:

  C20H24O4

• Molecular Weight:

  328.40

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Chen B, et al. Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells. Biomed Res Int. 2015;2015:829513.|[2]Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. Eur J Pharmacol. 2013 Mar 5;703 (1-3) :1-10.|[3]Choudhary S, et al. Crocetin Delays Brain and Body Aging by Increasing Cellular Energy Levels in Aged C57BL/6J Mice. ACS Pharmacol Transl Sci. 2024 Sep 11;7 (10) :3017-3033.|[4]Lautenschläger M, et al. Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22 (1) :36-44.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2; NMDA Receptor

• CAS Number:

  [27876-94-4]