IF5A1 rabbit pAb

• Background :

  Function:The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond., PTM:eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine) ., similarity:Belongs to the eIF-5A family., subunit:Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4., tissue specificity:Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level) .

• Description :

  Function: The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond. PTM: eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine). similarity: Belongs to the eIF-5A family. subunit: Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4. tissue specificity: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).

• UniProt :

  P63241

• Swiss Prot :

  P63241

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  16kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  16kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (PubMed:19379712, PubMed:27306458) . Nuclear export of hypusinated protein is mediated by XPO4 (PubMed:10944119, PubMed:27306458) . .

• Gene ID (Human) :

  1984