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IF5A1 rabbit pAb

CAT: 0855-ES11898-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11898-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond., PTM:eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine) ., similarity:Belongs to the eIF-5A family., subunit:Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4., tissue specificity:Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level) .
Description
Function: The precise role of eIF-5A in protein biosynthesis is not known but it functions by promoting the formation of the first peptide bond. PTM: eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine). similarity: Belongs to the eIF-5A family. subunit: Found in a complex with Ran and XPO4. The hypusine modification increases the interaction with XPO4. tissue specificity: Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
UniProt
P63241
Swiss Prot
P63241
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein
Target
IF5A1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
16kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
16kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions (PubMed:19379712, PubMed:27306458) . Nuclear export of hypusinated protein is mediated by XPO4 (PubMed:10944119, PubMed:27306458) . .
Gene ID (Human)
1984

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