Products for Research Use Only
RegisterLogin

FKB1A rabbit pAb

CAT: 0855-ES11839-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES11839-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided b
Description
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided b
UniProt
P62942
Swiss Prot
P62942
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein AA range: 1-50
Target
FKB1A
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
11kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
11kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
Gene ID (Human)
2280

UniProtKB · P62942

Peptidyl-prolyl cis-trans isomerase FKBP1A

FKB1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P62942
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FKBP1A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PPIase FKBP1A
EC number
5.2.1.8
Processing
—
Secondary accessions
D3DVW6, P20071, Q4VC47, Q6FGD9, Q6LEU3, Q9H103, Q9H566
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Cellular component

CytoplasmMembraneSarcoplasmic reticulum

Molecular function

IsomeraseRotamase

Related Products

CatalogName
ES16396-01FKB11 rabbit pAb
ES16397-01FKB10 rabbit pAb
ES11010-01FKB1B rabbit pAb
ES16395-01FKB15 rabbit pAb
ES16393-01FKBP1A/B rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb

Alternative Products

CatalogName
E28PN2893FKB1A Rabbit Polyclonal Antibody
GTR18054890-01FKB1A rabbit pAb Antibody
PAV1452Rabbit Anti-FKB1A/FKBP1A Polyclonal Antibody
C43790-01FKB1A Antibody
536334-01FKB1A discontinued
JOT-AP15597-01FKB1A Polyclonal Antibody
STJ192997Anti-FKB1A antibody
WP3268-01U-Blot® FKB1A Polyclonal Antibody
RTR015Rabbit-to-Rabbit Blocking Reagent
AR05252PU-NRabbit IgG Rabbit Protein

Popular Products