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ANF rabbit pAb

CAT: 0855-ES11830-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11830-01Size:50 µL
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Background
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015]
Description
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1. [provided by RefSeq, Oct 2015],
UniProt
P01160
Swiss Prot
P01160
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein
Target
ANF
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
16kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
16kD
Fragment
IgG
Subcellular Location
[Long-acting natriuretic peptide]: Secreted . Detected in blood. .; [Vessel dilator]: Secreted . Detected in blood. .; [Kaliuretic peptide]: Secreted . Detected in blood. .; [Urodilatin]: Secreted . Detected in urine (PubMed:2972874, PubMed:9794555, PubMed:8351194, PubMed:8779891) . Not detected in blood (PubMed:8351194) . Increased electrolytes, osmolality and intracellular cAMP levels increase peptide secretion/excretion (PubMed:9893117, PubMed:8853410, PubMed:8351194, PubMed:8779891) . .; [Atrial natriuretic peptide]: Secreted . Perikaryon . Cell projection . Detected in blood (PubMed:8351194, PubMed:8779891, PubMed:7955907, PubMed:8653797, PubMed:15741263, PubMed:18835931, PubMed:2532366, PubMed:7984506) . Detected in urine in one study (PubMed:8351194) . However, in another study, was not
Gene ID (Human)
4878

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