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MVP rabbit pAb

CAT: 0855-ES11827-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11827-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Description
This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012],
UniProt
Q14764
Swiss Prot
Q14764
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
98kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
98kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus, nuclear pore complex . Cytoplasm, perinuclear region . 5% found in the nuclear pore complex (PubMed:15133037) . Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665) .
Gene ID (Human)
9961

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