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ASM rabbit pAb

CAT: 0855-ES11798-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11798-02Size:100 µL
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Background
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB) . Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]
Description
The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010],
UniProt
P17405
Swiss Prot
P17405
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
69kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
69kD
Fragment
IgG
Subcellular Location
Lysosome . Lipid droplet . Secreted . The secreted form is induced in a time- and dose-dependent by IL1B and TNF as well as stress and viral infection. This increase of the secreted form seems to be due to exocytosis of the lysosomal form and is Ca (2+) -dependent (PubMed:20807762, PubMed:22573858, PubMed:20530211) . Secretion is dependent of phosphorylation at Ser-510 (PubMed:17303575) . Secretion is induced by inflammatory mediators such as IL1B, IFNG or TNF as well as infection with bacteria and viruses (PubMed:12563314, PubMed:20807762) . .
Gene ID (Human)
6609

UniProtKB · P17405

Sphingomyelin phosphodiesterase

ASM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17405
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SMPD1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.4.12, 3.1.4.3
Processing
Precursor
Secondary accessions
A8K8M3, E9PKS3, P17406, Q13811, Q16837, Q16841
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantNeurodegenerationNiemann-Pick disease

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

GlycosidaseHydrolase

Biological process

Host-virus interactionLipid metabolism

Cellular component

Lipid dropletLysosomeSecreted

Ligand

Metal-bindingZinc

Domain

Signal

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