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D5R agonist 1

CAT: 0804-HY-169116-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169116-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D5R agonist 1 (Compound 5j) is a selective, orally active and BBB penetrable D5R partial agonist (EC50: 269.7 nM). D5R agonist 1 enhances the cognition in the Scopolamine -induced amnesia model[1].
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d5r-agonist-1.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(C2=CC(OC)=C(OC)C=C2OC)=CC(C3=CC=C(I)C=C3)=N1
Molecular Formula
C19H18IN3O3
Molecular Weight
463.27
References & Citations
[1]Kumar S, et al. Discovery and structure - activity relationships of 2,4,5-trimethoxyphenyl pyrimidine derivatives as selective D5 receptor partial agonists. Bioorg Chem. 2024 Sep 7;153:107809.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D5 Receptor

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