MRGRD rabbit pAb

• Background:

  Function:May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca (2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G (q) and G (i) ., similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily., subcellular location:Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.

• Description:

  Function: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca (2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G (q) and G (i). similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. subcellular location: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.

• Gene ID:

  116512

• UniProt:

  Q8TDS7

• Cellular Locus:

  Cell membrane ; Multi-pass membrane protein. Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from part region of human protein

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C / 1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  35kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  35kD

• Subcellular Location:

  Cell membrane ; Multi-pass membrane protein . Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.

• Gene ID (Human):

  116512

• SwissProt (Human):

  Q8TDS7