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PARP9 rabbit pAb

CAT: 0855-ES11274-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11274-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:NAD (+) + (ADP-D-ribosyl) (n) -acceptor = nicotinamide + (ADP-D-ribosyl) (n+1) -acceptor., miscellaneous:Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration., similarity:Contains 1 PARP catalytic domain., similarity:Contains 2 Macro domains., subunit:Interacts with BBAP., tissue specificity:Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.
Description
Catalytic activity: NAD (+) + (ADP-D-ribosyl) (n)-acceptor = nicotinamide + (ADP-D-ribosyl) (n+1)-acceptor. miscellaneous: Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. similarity: Contains 1 PARP catalytic domain. similarity: Contains 2 Macro domains. subunit: Interacts with BBAP. tissue specificity: Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.
UniProt
Q8IXQ6
Swiss Prot
Q8IXQ6
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 450-530
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
93kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
93kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Nucleus . Shuttles between the nucleus and the cytosol (PubMed:16809771) . Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788) . Export to the cytosol depends on the interaction with DTX3L (PubMed:16809771) . Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742) . .
Gene ID (Human)
83666

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