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PARP-1 rabbit pAb

CAT: 0855-ES14255-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES14255-01Size:50 µL
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Background
This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl) transferase, which modifies various nuclear proteins by poly (ADP-ribosyl) ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Description
This gene encodes a chromatin-associated enzyme, poly (ADP-ribosyl)transferase, which modifies various nuclear proteins by poly (ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],
UniProt
P09874
Swiss Prot
P09874
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PARP-1
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, WB 1:500-2000
Molecular Weight
113kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
113kD
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
Other Product Names
Poly [ADP-ribose] polymerase 1 (PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD (+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1)
Gene ID (Human)
142

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