BEX3 rabbit pAb

• Background :

  Domain:The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR., function:May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity) . May play an important role in the pathogenesis of neurogenetic diseases., miscellaneous:Binds transition metals., PTM:Ubiquitinated. Degraded by the proteasome., similarity:Belongs to the BEX family., subcellular location:Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria., subunit:Self-associates. Interacts with 14-3-3 epsilon (YWHAE) . Interacts with DIABLO/SMAC (By similarity) . Binds to the DEATH domain of p75NTR/NGFR., tissue specificity:Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.

• Description :

  Domain: The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR. function: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. miscellaneous: Binds transition metals. PTM: Ubiquitinated. Degraded by the proteasome. similarity: Belongs to the BEX family. subcellular location: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. subunit: Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR. tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.

• UniProt :

  Q00994

• Swiss Prot :

  Q00994

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 1-80

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  12kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  12kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria (By similarity) . .

• Gene ID (Human) :

  27018