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NR1H4 rabbit pAb

CAT: 0855-ES11107-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11107-01Size:50 µL
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Background
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
Description
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016],
UniProt
Q96RI1
Swiss Prot
Q96RI1
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
53kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
53kD
Fragment
IgG
Subcellular Location
Nucleus .; [Isoform 1]: Nucleus .; [Isoform 2]: Nucleus .; [Isoform 3]: Nucleus .; [Isoform 4]: Nucleus .
Gene ID (Human)
9971

UniProtKB · Q96RI1

Bile acid receptor

NR1H4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96RI1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NR1H4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A1L4K5, B7Z412, B7ZM06, F8VYG8, Q8NFP5, Q8NFP6, Q92943
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingReceptorRepressor

Coding sequence diversity

Alternative promoter usageAlternative splicing

Disease

Disease variantIntrahepatic cholestasis

Biological process

ImmunityInflammatory responseInnate immunityTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Domain

Zinc-finger

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