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PGS2 rabbit pAb

CAT: 0855-ES11101-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11101-02Size:100 µL
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Background
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Description
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015],
UniProt
P07585
Swiss Prot
P07585
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
PGS2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
39kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
39kD
Fragment
IgG
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Gene ID (Human)
1634

UniProtKB · P07585

Decorin

PGS2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07585
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DCN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9
Protein keywords

Coding sequence diversity

Alternative splicing

Disease

Corneal dystrophy

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinProteoglycan

Cellular component

Extracellular matrixSecreted

Domain

Leucine-rich repeatRepeatSignal

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