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P3C2A rabbit pAb

CAT: 0855-ES10785-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10785-01Size:50 µL
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Background
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008],
UniProt
O00443
Swiss Prot
O00443
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
185kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
185kD
Fragment
IgG
Subcellular Location
Cell membrane . Cytoplasmic vesicle, clathrin-coated vesicle . Nucleus . Cytoplasm . Golgi apparatus, trans-Golgi network . Inserts preferentially into membranes containing PtdIns (4,5) P2 (PubMed:17038310) . Associated with RNA-containing structures (PubMed:11606566) . .
Gene ID (Human)
5286

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