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MIB2 rabbit pAb

CAT: 0855-ES10756-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES10756-01Size:50 µL
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Background
Function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors., induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene., pathway:Protein modification; protein ubiquitination., PTM:Ubiquitinated. Possibly via autoubiquitination., similarity:Contains 1 ZZ-type zinc finger., similarity:Contains 2 MIB/HERC2 domains., similarity:Contains 2 RING-type zinc fingers., similarity:Contains 9 ANK repeats., subcellular location:Colocalizes with endosomal compartments., subunit:Interacts with actin monomer., tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Description
Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. induction: Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene. pathway: Protein modification; protein ubiquitination. PTM: Ubiquitinated. Possibly via autoubiquitination. similarity: Contains 1 ZZ-type zinc finger. similarity: Contains 2 MIB/HERC2 domains. similarity: Contains 2 RING-type zinc fingers. similarity: Contains 9 ANK repeats. subcellular location: Colocalizes with endosomal compartments. subunit: Interacts with actin monomer. tissue specificity: Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
UniProt
Q96AX9
Swiss Prot
Q96AX9
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from part region of human protein
Target
MIB2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
111kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
111kD
Fragment
IgG
Subcellular Location
Cytoplasm . Endosome . Colocalizes with endosomal compartments.
Gene ID (Human)
142678

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