MIB2 rabbit pAb

• Background:

  Function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors., induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene., pathway:Protein modification; protein ubiquitination., PTM:Ubiquitinated. Possibly via autoubiquitination., similarity:Contains 1 ZZ-type zinc finger., similarity:Contains 2 MIB/HERC2 domains., similarity:Contains 2 RING-type zinc fingers., similarity:Contains 9 ANK repeats., subcellular location:Colocalizes with endosomal compartments., subunit:Interacts with actin monomer., tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.

• Description:

  Function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. induction: Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene. pathway: Protein modification; protein ubiquitination. PTM: Ubiquitinated. Possibly via autoubiquitination. similarity: Contains 1 ZZ-type zinc finger. similarity: Contains 2 MIB/HERC2 domains. similarity: Contains 2 RING-type zinc fingers. similarity: Contains 9 ANK repeats. subcellular location: Colocalizes with endosomal compartments. subunit: Interacts with actin monomer. tissue specificity: Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.

• UniProt:

  Q96AX9

• Swiss Prot:

  Q96AX9

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized peptide derived from part region of human protein

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  111kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  111kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Endosome . Colocalizes with endosomal compartments.

• Gene ID (Human):

  142678