DEDD rabbit pAb

CAT: 0855-ES10681-01Size: 50 µLDry Ice: NoHazardous: No

1 / 1

CAT#:0855-ES10681-01Size:50 µL

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

This gene encodes a protein that contains a death effector domain (DED) . DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

UniProt

O75618

Swiss Prot

O75618

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human protein . at AA range: 90-170

Target

DEDD

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

34kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

34kD

Fragment

IgG

Subcellular Location

Cytoplasm. Nucleus, nucleolus . Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity) . Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. .

Gene ID (Human)

9191

UniProtKB · O75618

Death effector domain-containing protein

DEDD_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O75618
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: DEDD
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: D3DVF5, O60737

Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisTranscriptionTranscription regulation

Cellular component

CytoplasmNucleus

Molecular function

DNA-bindingRepressor

Technical term

Proteomics identificationReference proteome

PTM

Ubl conjugation

Related Products

Catalog	Name
ES19264-01	DEDD2 rabbit pAb
ES4666-01	RAB3IP rabbit pAb
ES20751-01	Gab1 Rabbit rabbit pAb
ES20703-01	JAK2 Rabbit rabbit pAb
ES20758-01	ERK1 Rabbit rabbit pAb
ES20830-01	ATG14L Rabbit rabbit pAb
ES20829-01	ATG4a Rabbit rabbit pAb
ES20658-01	NM23A Rabbit rabbit pAb
ES20826-01	ATG5 Rabbit rabbit pAb
ES20659-01	NBR1 Rabbit rabbit pAb

Alternative Products

Catalog	Name
A5806	DEDD Rabbit pAb
MBS9514192-01	DEDD Rabbit Polyclonal Antibody
GTR18054234-01	DEDD rabbit pAb Antibody
NBP2-68959-25ul	Rabbit Polyclonal DEDD Antibody
APR26118N-01	DEDD Rabbit pAb (APR26118N)
GTR18341514	DEDD Rabbit Polyclonal Antibody (Biotin)
GTR18341513	DEDD Rabbit Polyclonal Antibody (FITC)
PA14374-01	Rabbit Anti-Human DEDD pAb
GTR18341511	DEDD Rabbit Polyclonal Antibody (HRP)
GTR18210524	DEDD (N2) Antibody, Rabbit Polyclonal