HES2 rabbit pAb

• Background :

  Domain:Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG) ., domain:The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins., function:Transcriptional repressor of genes that require a bHLH protein for their transcription., similarity:Contains 1 basic helix-loop-helix (bHLH) domain., similarity:Contains 1 Orange domain., subunit:Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family., tissue specificity:Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.

• Description :

  Domain: Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). Domain: The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins. function: Transcriptional repressor of genes that require a bHLH protein for their transcription. similarity: Contains 1 basic helix-loop-helix (bHLH) domain. similarity: Contains 1 Orange domain. subunit: Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. tissue specificity: Expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.

• UniProt :

  Q9Y543

• Swiss Prot :

  Q9Y543

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 40-120

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  19kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  19kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus .

• Gene ID (Human) :

  54626