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CPEB1 rabbit pAb

CAT: 0855-ES10644-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10644-01Size:50 µL
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Background
This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Description
This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
UniProt
Q9BZB8
Swiss Prot
Q9BZB8
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
62kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
62kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Cytoplasm, P-body. Cytoplasmic granule. Cell junction, synapse. Membrane. Cell junction, synapse, postsynaptic density . Cell projection, dendrite . Continuously shuttling between nucleus and cytoplasm (PubMed:18923137) . Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity) . Localizes in synaptosomes at dendritic synapses of neurons (By similarity) . Strongly enriched in postsynaptic density (PSD) fractions (By similarity) . Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity) . Membrane-associated (By similarity) . Colocalizes at excitatory synapses with members of the polyadenylation and translation comple
Gene ID (Human)
64506

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