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KDM3B rabbit pAb

CAT: 0855-ES10593-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10593-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cofactor:Binds 1 Fe (2+) ion per subunit., domain:Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors., function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity., miscellaneous:Its gene is located in the 5q region of the genome which is deleted in del (5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del (5q) tumor suppressor gene., similarity:Belongs to the JHDM2 histone demethylase family., similarity:Contains 1 JmjC domain., tissue specificity:Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
Description
Cofactor: Binds 1 Fe (2+) ion per subunit. Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. miscellaneous: Its gene is located in the 5q region of the genome which is deleted in del (5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del (5q) tumor suppressor gene. similarity: Belongs to the JHDM2 histone demethylase family. similarity: Contains 1 JmjC domain. tissue specificity: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
UniProt
Q7LBC6
Swiss Prot
Q7LBC6
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
193kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
193kD
Fragment
IgG
Subcellular Location
Nucleus .
Gene ID (Human)
51780

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