KDM3B rabbit pAb

• Background:

  Cofactor:Binds 1 Fe (2+) ion per subunit., domain:Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors., function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity., miscellaneous:Its gene is located in the 5q region of the genome which is deleted in del (5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del (5q) tumor suppressor gene., similarity:Belongs to the JHDM2 histone demethylase family., similarity:Contains 1 JmjC domain., tissue specificity:Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.

• Description:

  Cofactor: Binds 1 Fe (2+) ion per subunit. Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors. function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. miscellaneous: Its gene is located in the 5q region of the genome which is deleted in del (5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del (5q) tumor suppressor gene. similarity: Belongs to the JHDM2 histone demethylase family. similarity: Contains 1 JmjC domain. tissue specificity: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.

• Gene ID:

  51780

• UniProt:

  Q7LBC6

• Cellular Locus:

  Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Reactivity:

  Human; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 230-310

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  193kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  193 kD

• Subcellular Location:

  Nucleus .

• Gene ID (Human):

  51780

• SwissProt (Human):

  Q7LBC6