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M3K12 rabbit pAb

CAT: 0855-ES10539-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10539-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Description
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2010],
UniProt
Q12852
Swiss Prot
Q12852
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 730-810
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
94kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
94kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane . Behaves essentially as an integral membrane protein. .
Gene ID (Human)
7786

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