CUL5 rabbit pAb

CAT: 0855-ES10533-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES10533-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Function:Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS (SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor., pathway:Protein modification; protein ubiquitination., PTM:Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex., similarity:Belongs to the cullin family., subunit:Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS (LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS (SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS (WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS (SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS (SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS (SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS (SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS (RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.
Description
Function: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS (SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. pathway: Protein modification; protein ubiquitination. PTM: Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex. similarity: Belongs to the cullin family. subunit: Component of multiple ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes formed of CUL5, Elongin BC (TCEB1 and TCEB2), RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Component of the probable ECS (LRRC41) complex with the substrate recognition component LRRC41. Component of the probable ECS (SOCS1) complex with the substrate recognition component SOCS1. Component of the probable ECS (WSB1) complex with the substrate recognition subunit WSB1. Component of the probable ECS (SOCS3) complex with the substrate recognition component SOCS3. Component of the probable ECS (SPSB1) complex with the substrate recognition component SPSB1. Component of the probable ECS (SPSB2) complex with the substrate recognition component SPSB2. Component of the probable ECS (SPSB4) complex with the substrate recognition component SPSB4. Component of the probable ECS (RAB40C) complex with the substrate recognition subunit RAB40C. May also form complexes containing CUL5, elongin BC complex (TCEB1 and TCEB2), RBX1 and TCEB3. May also form complexes containing CUL5, Elongin BC (TCEB1 and TCEB2), RBX1 and VHL. The substrate recognition component can also be a viral protein such as HIV Vif, or human adenovirus 5 E1B large T-antigen and E4-orf6. Interacts with RNF7/RBX2, LRRC41, SOCS3, SPSB1, SPSB2, SPSB4 and RAB40C. Interacts with ASB1, ASB2, ASB6, ASB7 and ASB12.
UniProt
Q93034
Swiss Prot
Q93034
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 560-640
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
85kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85kD
Fragment
IgG
Subcellular Location
Cytosol, cullin-RING ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex
Gene ID (Human)
8065

Related Products

CatalogName
ES10534-01CUL7 rabbit pAb
ES2072-01CUL-1 rabbit pAb
ES2073-01CUL-2 rabbit pAb
ES3918-01CUL-4B rabbit pAb
ES2074-01CUL-3 rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20599-01VEGF Rabbit rabbit pAb

Alternative Products

CatalogName
A5369-01CUL5 Rabbit pAb
APR25771N-01CUL5 Rabbit pAb (APR25771N)
E53P11988CUL5 Rabbit Polyclonal Antibody
E2616291CUL5 (C-term) Rabbit pAb
PAV1070Rabbit Anti-Cul5 Polyclonal Antibody
PA14003-01Rabbit Anti-Human Cul5 pAb
TA332647Cullin 5 (CUL5) Rabbit Polyclonal Antibody
ELI-25947RaRabbit Cullin-5,CUL5 ELISA KIT
MBS284482-01Rabbit Cullin-5 (CUL5) ELISA Kit
GTR10332776Rabbit Cullin 5 (CUL5) ELISA Kit

Popular Products