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VPP2 rabbit pAb

CAT: 0855-ES10462-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10462-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V (1) domain for ATP hydrolysis, and an integral membrane V (0) domain for proton translocation. The subunit encoded by this gene is a component of the V (0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]
Description
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V (1) domain for ATP hydrolysis, and an integral membrane V (0) domain for proton translocation. The subunit encoded by this gene is a component of the V (0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009],
UniProt
Q9Y487
Swiss Prot
Q9Y487
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
94kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
94kD
Fragment
IgG
Subcellular Location
Cell membrane; Multi-pass membrane protein. Endosome membrane. In kidney proximal tubules, also detected in subapical vesicles. .
Gene ID (Human)
23545

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