VPP2 rabbit pAb

• Background :

  The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V (1) domain for ATP hydrolysis, and an integral membrane V (0) domain for proton translocation. The subunit encoded by this gene is a component of the V (0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]

• Description :

  The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V (1) domain for ATP hydrolysis, and an integral membrane V (0) domain for proton translocation. The subunit encoded by this gene is a component of the V (0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009],

• UniProt :

  Q9Y487

• Swiss Prot :

  Q9Y487

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  94kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  94kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane; Multi-pass membrane protein. Endosome membrane. In kidney proximal tubules, also detected in subapical vesicles. .

• Gene ID (Human) :

  23545