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UBP6 rabbit pAb

CAT: 0855-ES10424-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10424-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., disease:Involved in tumorigenesis., function:Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity., miscellaneous:The USP6 gene only exists in the primate lineage., similarity:Belongs to the peptidase C19 family., similarity:Contains 1 Rab-GAP TBC domain., tissue specificity:Testis specific. Expressed in various cancer cell lines.
Description
Catalytic activity: Ubiquitin C-terminal thioester + H (2)O = ubiquitin + a thiol. Disease: Involved in tumorigenesis. function: Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. miscellaneous: The USP6 gene only exists in the primate lineage. similarity: Belongs to the peptidase C19 family. similarity: Contains 1 Rab-GAP TBC domain. tissue specificity: Testis specific. Expressed in various cancer cell lines.
UniProt
P35125
Swiss Prot
P35125
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
154kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
154kD
Fragment
IgG
Subcellular Location
Cell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
Gene ID (Human)
9098

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