3BP1 rabbit pAb
CAT:
855-ES10250-02
Size:
100 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
3BP1 rabbit pAb
- Description: Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. sequence Caution: Translated as Cys. similarity: Contains 1 BAR domain. similarity: Contains 1 Rho-GAP domain.
- Gene ID: 23616
- UniProt: Q9Y3L3
- Cellular Locus: Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol. Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210)..
- Host: Rabbit
- Species Reactivity: Human, Mouse
- Immunogen: Synthesized peptide derived from human protein . at AA range: 170-250
- Clonality: Polyclonal
- Validated Applications: WB, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: WB 1:500-2000 ELISA 1:5000-20000
- Molecular Weight: 77kD
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.