3BP1 rabbit pAb

CAT: 0855-ES10250-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES10250-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac., sequence caution:Translated as Cys., similarity:Contains 1 BAR domain., similarity:Contains 1 Rho-GAP domain.
Description
Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. sequence Caution: Translated as Cys. similarity: Contains 1 BAR domain. similarity: Contains 1 Rho-GAP domain.
UniProt
Q9Y3L3
Swiss Prot
Q9Y3L3
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 170-250
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
77kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
77kD
Fragment
IgG
Subcellular Location
Cell projection . Cell junction, tight junction . Cell junction, adherens junction . Cell projection, phagocytic cup . Nucleus . Cytoplasm, cytosol . Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563) . Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210) . .
Gene ID (Human)
23616

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