SH2B3 rabbit pAb

• Background:

  This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

• Description:

  This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and Cytokine receptors. The encoded protein is a key negative regulator of Cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014],

• UniProt:

  Q9UQQ2

• Swiss Prot:

  Q9UQQ2

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from part region of human protein

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  63kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  63kD

• Fragment:

  IgG

• Subcellular Location:

  Cytosol

• Gene ID (Human):

  10019