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SH2B3 rabbit pAb

CAT: 0855-ES10242-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10242-01Size:50 µL
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Background
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Description
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and Cytokine receptors. The encoded protein is a key negative regulator of Cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014],
UniProt
Q9UQQ2
Swiss Prot
Q9UQQ2
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
63kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
63kD
Fragment
IgG
Subcellular Location
Cytosol
Gene ID (Human)
10019

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