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PTPRT rabbit pAb

CAT: 0855-ES10144-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10144-02Size:100 µL
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],
UniProt
O14522
Swiss Prot
O14522
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 200-280
Target
PTPRT
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
158kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
158kD
Fragment
IgG
Subcellular Location
Membrane; Single-pass type I membrane protein.
Gene ID (Human)
11122

UniProtKB · O14522

Receptor-type tyrosine-protein phosphatase T

PTPRT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14522
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PTPRT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
R-PTP-T
EC number
3.1.3.48
Processing
Precursor
Secondary accessions
A8E4R6, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

HydrolaseProtein phosphataseReceptor

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

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