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RPGF6 rabbit pAb

CAT: 0855-ES10095-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10095-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 cyclic nucleotide-binding domain., similarity:Contains 1 N-terminal Ras-GEF domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 Ras-associating domain., similarity:Contains 1 Ras-GEF domain., subcellular location:Upon binding to M-Ras, it translocates to the plasma membrane., subunit:Interacts with the second PDZ domain of human PTP1e., tissue specificity:Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.
Description
Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 cyclic nucleotide-binding domain. similarity: Contains 1 N-terminal Ras-GEF domain. similarity: Contains 1 PDZ (DHR) domain. similarity: Contains 1 Ras-associating domain. similarity: Contains 1 Ras-GEF domain. subcellular location: Upon binding to M-Ras, it translocates to the plasma membrane. subunit: Interacts with the second PDZ domain of human PTP1e. tissue specificity: Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.
UniProt
Q8TEU7
Swiss Prot
Q8TEU7
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 460-540
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
176kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
176kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane . Upon binding to M-Ras, it translocates to the plasma membrane.
Gene ID (Human)
51735

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