RPGF4 rabbit pAb

• Background :

  Domain:The DEP domain is involved in membrane localization independent from regulation by cAMP., domain:The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2., function:Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2., similarity:Contains 1 DEP domain., similarity:Contains 1 N-terminal Ras-GEF domain., similarity:Contains 1 Ras-GEF domain., similarity:Contains 2 cyclic nucleotide-binding domains., subunit:Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A., tissue specificity:Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

• Description :

  Domain: The DEP domain is involved in membrane localization independent from regulation by cAMP. Domain: The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2. function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. similarity: Contains 1 DEP domain. similarity: Contains 1 N-terminal Ras-GEF domain. similarity: Contains 1 Ras-GEF domain. similarity: Contains 2 cyclic nucleotide-binding domains. subunit: Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. tissue specificity: Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.

• UniProt :

  Q8WZA2

• Swiss Prot :

  Q8WZA2

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 240-320

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  111kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  111kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm. Membrane ; Peripheral membrane protein .

• Gene ID (Human) :

  11069