PHC3 rabbit pAb

• Background :

  Function:Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 FCS-type zinc finger., similarity:Contains 1 SAM (sterile alpha motif) domain., subunit:Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2.

• Description :

  Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 FCS-type zinc finger. similarity: Contains 1 SAM (sterile alpha motif) domain. subunit: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2.

• UniProt :

  Q8NDX5

• Swiss Prot :

  Q8NDX5

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 720-800

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  108kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  108kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus .

• Gene ID (Human) :

  80012