PPIG rabbit pAb

PPIG rabbit pAb

• Description: Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0). Domain: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II. enzyme regulation: Cyclosporin A (CsA)-sensitive. function: PPIases accelerate the folding of proteins. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the cyclophilin-type PPIase family. similarity: Contains 1 PPIase cyclophilin-type domain. subcellular location: Colocalizes with RNA splicing factors at nuclear speckles. subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II. tissue specificity: Ubiquitous.
• Gene ID: 9360
• UniProt: Q13427
• Cellular Locus: Nucleus matrix. Nucleus speckle. Colocalizes with RNA splicing factors at nuclear speckles..
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthesized peptide derived from human protein . at AA range: 290-370
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000 ELISA 1:5000-20000
• Molecular Weight: 82kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.