NU133 rabbit pAb

CAT: 0855-ES9936-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES9936-01Size:50 µL
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Background
Nucleoporin 133 (NUP133) Homo sapiens The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]
Description
Nucleoporin 133 (NUP133) Homo sapiens The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008],
UniProt
Q8WUM0
Swiss Prot
Q8WUM0
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 830-910
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
127kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
127kD
Fragment
IgG
Subcellular Location
Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755) . During mitosis, localizes to the kinetochores (PubMed:11564755) . .
Gene ID (Human)
55746

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