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MYO15 rabbit pAb

CAT: 0855-ES9857-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9857-01Size:50 µL
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Background
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
Description
This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008],
UniProt
Q9UKN7
Swiss Prot
Q9UKN7
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 2990-3070
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1:50-300
Molecular Weight
388kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
388kD
Fragment
IgG
Subcellular Location
Cell projection, stereocilium . Cytoplasm, cytoskeleton . Localizes to stereocilium tips in cochlear and vestibular hair cells. .
Gene ID (Human)
51168

UniProtKB · Q9UKN7

Unconventional myosin-XV

MYO15_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UKN7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYO15A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DFC7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-bindingCalmodulin-bindingMotor proteinMyosin

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell projectionCytoplasmCytoskeleton

Domain

Coiled coilRepeatSH3 domain

Disease

DeafnessDisease variantNon-syndromic deafness

Biological process

Hearing

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