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MYO3A rabbit pAb

CAT: 0855-ES9843-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9843-01Size:50 µL
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Background
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase domain N-terminal to the conserved N-terminal motor domains and are expressed in photoreceptors. The protein encoded by this gene plays an important role in hearing in humans. Three different recessive, loss of function mutations in the encoded protein have been shown to cause nonsyndromic progressive hearing loss. Expression of this gene is highly restricted, with the strongest expression in retina and cochlea. [provided by RefSeq, Jul 2008],
UniProt
Q8NEV4
Swiss Prot
Q8NEV4
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 180-260
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
177kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
177kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm . Cell projection, filopodium tip . Cell projection, stereocilium . Increased localization at the filodium tip seen in the presence of MORN4. .
Gene ID (Human)
53904

UniProtKB · Q8NEV4

Myosin-IIIa

MYO3A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NEV4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MYO3A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
Q4G0X2, Q5VZ28, Q8WX17, Q9NYS8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

Actin-bindingKinaseMotor proteinMyosinSerine/threonine-protein kinaseTransferase

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell projectionCytoplasmCytoskeleton

Disease

DeafnessDisease variantNon-syndromic deafness

Biological process

HearingSensory transductionVision

Domain

Repeat

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