Products for Research Use Only
RegisterLogin

2B1F rabbit pAb

CAT: 0855-ES9712-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES9712-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Major histocompatibility complex, class II, DR beta 1 (HLA-DRB1) Homo sapiens HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney t
Description
Major histocompatibility complex, class II, DR beta 1 (HLA-DRB1) Homo sapiens HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney t
UniProt
P01911
Swiss Prot
P01911
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein AA range: 181-230
Target
2B1F
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
29kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
29kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Autolysosome membrane . The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation (PubMed:18305173) . Component of immunological synapses at the interface between T cell and APC (PubMed:29884618) . .
Gene ID (Human)
3123

Related Products

CatalogName
ES18542-012B13 rabbit pAb
ES18538-012B1G rabbit pAb
ES18539-012B1E rabbit pAb
ES18541-012B17 rabbit pAb
ES18540-012B1B rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb

Alternative Products

CatalogName
E28PN07662B1F Rabbit Polyclonal Antibody
GTR18053683-012B1F rabbit pAb Antibody
532531-012B1F discontinued
C42393-012B1F Antibody
JOT-AP08347-012B1F Polyclonal Antibody
STJ190870Anti-2B1F antibody
E100838Human 2B1F ELISA Kit
WP1190-01U-Blot® 2B1F Polyclonal Antibody
336102-01SULT2B1 (Sulfotransferase Family Cytosolic 2B Member 1, Alcohol Sulfotransferase, EC 2.8.2.2, Hydroxysteroid Sulfotransferase 2, ST2B1, Sulfotransferase 2B1f, SULT 2 B 1, Sult2b, SULT2B1a, SULT2B1b)
RTR015Rabbit-to-Rabbit Blocking Reagent

Popular Products