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2B1F Polyclonal Antibody

CAT: 0965-JOT-AP08347-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP08347-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB)| both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes| dendritic cells| macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney t
CAS Number
9007-83-4
Synonyms
HLA class II histocompatibility antigen; DRB1-15 beta chain ;DW2.2/DR2.2;MHC class II antigen DRB1*15
Host
Rabbit
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Antibody Type
Primary antibody
Isotype
IgG