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APBB1 rabbit pAb

CAT: 0855-ES9386-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9386-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Amyloid beta precursor protein binding family B member 1 (APBB1) Homo sapiens The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012]
Description
Amyloid beta precursor protein binding family B member 1 (APBB1) Homo sapiens The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012],
UniProt
O00213
Swiss Prot
O00213
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 400-480
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
78kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
78kD
Fragment
IgG
Subcellular Location
Cell membrane . Cytoplasm . Nucleus . Cell projection, growth cone . Nucleus speckle . Colocalizes with TSHZ3 in axonal growth cone (By similarity) . Colocalizes with TSHZ3 in the nucleus (PubMed:19343227) . In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999) . Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999) . Nuclear translocation is under the regulation of APP (PubMed:18468999) . Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906) . Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity) . .
Gene ID (Human)
322

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