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APBB1 Rabbit pAb (APR24486N)

CAT: 0882-APR24486N-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0882-APR24486N-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality APBB1 Rabbit pAb (APR24486N) .
Synonyms
APBB1; FE65; MGC:9072; RIR
Gene ID
322
UniProt
O00213
Cellular Locus
Cell membrane, Cell projection, Cytoplasm, Nucleus, Nucleus speckle, growth cone
Dilution
WB 1:50 - 1:200 IHC 1:50 - 1:200 IF 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 49kDa/52kDa/53kDa/54kDa/76kDa/77kDa Observed MW: 63kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=322
Uniprot URL
https://www.uniprot.org/uniprot/O00213
AA Sequence
PPRNTNPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQSQALLHAQPIISIRVWGVGRDSGRDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMAERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQASTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGAHTP

UniProtKB · O00213

Amyloid beta precursor protein binding family B member 1

APBB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00213
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APBB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A1E379, A6NH82, A6NL69, B7Z1J5, B7Z1J6, B7Z2Y0, D3DQT2, Q7Z324, Q96A93, V9GYK0, V9GYT4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Molecular function

ActivatorChromatin regulatorRepressor

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisDNA damageTranscriptionTranscription regulation

Cellular component

Cell membraneCell projectionCytoplasmMembraneNucleus

Domain

Repeat

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