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CDC45 rabbit pAb

CAT: 0855-ES9250-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9250-02Size:100 µL
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Background
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Description
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
UniProt
O75419
Swiss Prot
O75419
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
62kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
62kD
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus.
Gene ID (Human)
8318

UniProtKB · O75419

Cell division control protein 45 homolog

CDC45_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75419
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDC45
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DDB4, B4DDU3, E9PDH7, O60856, Q20WK8, Q6UW54, Q9UP68
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleDNA replication

Cellular component

ChromosomeNucleus

Disease

Disease variantDwarfism

PTM

Phosphoprotein

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