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VNN2 rabbit pAb

CAT: 0855-ES9228-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9228-02Size:100 µL
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Background
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Description
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011],
UniProt
O95498
Swiss Prot
O95498
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 320-400
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
57kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
57kD
Fragment
IgG
Subcellular Location
Cell membrane ; Lipid-anchor, GPI-anchor .
Gene ID (Human)
8875

UniProtKB · O95498

Pantetheine hydrolase VNN2

VNN2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95498
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VNN2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.5.1.92
Processing
Precursor
Secondary accessions
A0AUZ3, A6NDY1, A8K4E3, A8K7W0, B2DFZ0, B2DFZ1, B2DFZ2, B2DFZ3, F6XL73, Q2XUN1, Q9UJF3, Q9UMW2
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

GlycoproteinGPI-anchorLipoprotein

Molecular function

Hydrolase

Technical term

Proteomics identificationReference proteome

Domain

Signal

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