CDA7L rabbit pAb

CDA7L rabbit pAb

• Description: Function: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. induction: By MYC overexpression in a concentration dependent manner in neuroblastoma cell line. miscellaneous: Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation. subcellular location: Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. subunit: Interacts with MYC and PSIP1. tissue specificity: Ubiquitous. Overexpressed in medulloblastoma.
• Gene ID: 55536
• UniProt: Q96GN5
• Cellular Locus: Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthesized peptide derived from human protein . at AA range: 140-220
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000 ELISA 1:5000-20000
• Molecular Weight: 49kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.