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LRP6 rabbit pAb

CAT: 0855-ES8988-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8988-02Size:100 µL
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Background
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Description
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. [provided by RefSeq, Dec 2009],
UniProt
O75581
Swiss Prot
O75581
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 1420-1500
Target
LRP6
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
177kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
177kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum . Membrane raft . On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity) . .
Gene ID (Human)
4040

UniProtKB · O75581

Low-density lipoprotein receptor-related protein 6

LRP6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75581
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LRP6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
LRP-6
EC number
—
Processing
Precursor
Secondary accessions
Q17RZ2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneEndoplasmic reticulumMembrane

Molecular function

Developmental proteinReceptor

Disease

Disease variantOsteopetrosis

PTM

Disulfide bondGlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Biological process

EndocytosisWnt signaling pathway

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